TY  - BOOK
AU  - Amani Magdi Nagi Mahmoud
AU  - Elham A. Hassan, 
AU  - Iman Bakr Shaheed , 
AU  - Mohamed Ayad Abdelhamid , 
TI  - Simvastatin as a growth promoting material on the healing of critical sized bone defect in dogs: : An experimental study / 
PY  - 2015///
CY  - Cairo : 
PB  - Amani Magdi Nagi Mahmoud , 
KW  - Critical sized bone defect
KW  - Healing
KW  - Simvastatin
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Surgery , Anesthesiology and Radiology; Issued also as CD
N2  - Critical size defect represents a major challenge in orthopedic surgery. The aim of the work was decided to study the effect of locally applied simvastatin as a growth promoting material on the healing of experimentally induced critical size bone defect in dogs. A prospective experimental study was done on 18 skeletally mature male mongrel dogs. A 21 mm mid-shaft femoral defect was induced in all dogs. Dogs were randomly allocated into one of the two groups; group 1:- simvastatin was locally applied into the defect site, group 2:- defects were kept without simvastatin (sham-operated group). All defect sites were stabilized using bone plate and screws. Dogs were evaluated clinically and radiographically every two weeks till 12 weeks. The dogs were euthanized at 4,8 and 12 weeks for gross pathologic and histopathologic examination (Hematoxyline & Eosin, Masson Trichrome, Alizarine red and immune histochemical evaluation (osteopontin)
UR  - http://172.23.153.220/th.pdf
ER  -