TY  - BOOK
AU  - Mohamed Salah Thabet
AU  - Hanan Zekry Khaled , 
AU  - Tamer Abdelhamed Dihome , 
AU  - Zahraa Mohamed Ezzeldein , 
TI  - Efficacy and safety of milrinone versus sildenafil in the management of moderate to severe peristent pulmonary hypertention in neonates / 
PY  - 2015///
CY  - Cairo : 
PB  - Mohamed Salah Thabet , 
KW  - Blood gases
KW  - PPHN
KW  - Systolic pulmonary artery pressure
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics; Issued also as CD
N2  - Background: Pulmonary hypertension in newborn (PPHN) is a critical problem facing neonatologists. Aim of the work: To determine the impact of management strategies on the outcome of PPHN. Patients and methods: Prospective descriptive study. 40 neonates with the diagnosis of PPHN who were admitted in NICUs in multi-centers from June 2014 to December 2014. Neonates divided into 2 equal groups one is treated by intravenous milrinone infusion and the other is treated by nasogastric sildenafil, it includes 33 males, 7 females; their mean gestational age was ±36.5weeks and the mean weight was 2.9 ± 0.5Kg. Results: Male neonates had higher incidence of PPHN 82.5% compared to females 17.5% .Neonates recived intravenous milrinone infusion shows statistical significant improvement than those recived nasogastric sildenafil in oxygenation index (OI)values 24 hrs after treatment(p{u2264}0.010), 48 hrs later (P{u2264} 0.001). Successful treatment was defined as drop of systolic pulmonary artery pressure (SPAP) below {u2264}40mmHg. There was statistical significant drop of SPAP after application ofmilrinone than sildenafil (P{u2264}0.040). The mortality rate was 10/40 neonates (25%)
UR  - http://172.23.153.220/th.pdf
ER  -