TY  - BOOK
AU  - Mai Gamal Eldin Sayed Sayed
AU  - Emad Emil Ghobrial , 
AU  - Huda Marzouk Mohammed , 
AU  - Mervat Mamdouh Ahmed Khorshied , 
TI  - Level of interleukin-37(IL-37) in children with  systemic lupus erythematosus and its correlation with disease activity / 
PY  - 2015///
CY  - Cairo : 
PB  - Mai Gamal Eldin Sayed Sayed , 
KW  - Interleukin37
KW  - SLEDAI-2K
KW  - Systemic lupus erythromatosus
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics; Issued also as CD
N2  - Background: Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by multiple auto-antibodies against self-directed  antigens and multisystemic involvement. The SLE Disease Activity Index (SLEDAI-2K) scoring system evaluates the presence of multiple features  of SLE flares at the time of completion or in the previous 10 days. Interleukin 37 (IL-37) is a newly defined member of cytokine family, and  it is a key cytokine in regulating inflammation. Objectives: we aimed to detect the level of IL-37 in SLE and correlate it  with the activity of disease. Results: Levels of IL-37 in 50 cases with SLE have higher than in 30 controls but without statistically significant difference (P =0.08). Level of  IL-37 in active cases with higher than in inactive cases but without  statistically significant difference (P =0.58). Level of IL-37 level in mild activity with lower than in moderate or severe active but without  statistically significant difference (P =0.23). Level of IL-37 is correlated  with delay in diagnosis of disease and SLEDAI-2K score.Conclusion: level of IL-37 is higher in SLE patients than controls and it is higher in active cases than inactive cases. IL-37 is correlated with lag  between onset and diagnosis of disease and SLEDAI-2K
UR  - http://172.23.153.220/th.pdf
ER  -