TY  - BOOK
AU  - Doaa Hussein Mobarak
AU  - Mahmoud Mohamed Ghourab , 
AU  - Salwa Mohamed Salah Eldin , 
TI  - Design, preparation and pharmaceutical evaluation of solid dosage forms for treatment of erectile dysfunction / 
PY  - 2015///
CY  - Cairo : 
PB  - Doaa Hussein Mobarak , 
KW  - Erectile dysfunction
KW  - Self emulsifying drug delivery system
KW  - Tadalafil
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics; Issued also as CD
N2  - Self-emulsifying drug delivery system has been proven to be a successful  tool to improve the solubility and therefore bioavailability of lipophilic  drugs. Upon dilution with the aqueous fluid and mild agitation the self- emulsifying components readily and quickly disperse into microemulsion.  Tadalafil is a phosphodiesterase type 5 inhibitor, with an elimination half- life (T1/2) 17.5 hours and 2 hours for the onset of action. Tadalafil is a  class II drug, with low solubility, thus having a bioavailability of  approximated 30%. Overcoming the delayed onset of action as well as  increasing the bioavailability was approached in this study
ER  -