TY  - BOOK
AU  - Asmaa Ahmed Elshafei
AU  - Dalia Ibrahim Ismail , 
AU  - Eman Mostafa Sadek , 
AU  - Nagla Mohamed Salama , 
TI  - A histological study on the protective effect of endogenous stem cells mobilization in adriamycin-induced chronic nephropathy in rats / 
PY  - 2015///
CY  - Cairo : 
PB  - Asmaa Ahmed Elshafei , 
KW  - Adriamycin
KW  - Chronic kidney disease
KW  - G-CSF
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Histology; Issued also as CD
N2  - Chronic kidney disease (CKD) is a global public health problem with increasing morbidity and mortality. Therefore, this study was planned to test the protective effect of hematopoietic stem cells mobilization by granulocyte-colony stimulating factor (G-CSF) on adriamycin (ADR)-induced chronic renal diseasein rats. Thirty albino rats were classified into three groups:  control, ADR group: rats received single intravenous injection of ADR(5mg/kg) and G-CSF group:  rats received ADR by the same route and the same dose asthe previous group then G-CSF (70æg/kg/day) two hours after ADR injectionthen daily for 5 consecutive days. At time of sacrifice (after 6 weeks), blood samples were taken toestimate blood urea nitrogen (BUN) &serum creatinine. Kidneys sections were stained with H&E, Masson{u2019}s trichrome, PAS stains&Immunohistochemichal staining against CD34 & caspase-3. G-CSF treated group exhibited protection against renal injury manifested by reducing blood urea nitrogenand serum creatinine levels,improving histological architecture and increasing theproliferative capacity of renal tubule
UR  - http://172.23.153.220/th.pdf
ER  -