TY  - BOOK
AU  - Emily Samir Mikhael Georgy
AU  - Lamia Mansour , 
AU  - Riham Elessawy , 
AU  - Riham Elsayed , 
TI  - Interleukin 17-A as an inflammatory marker of  multiple organ dysfunction syndrome in patients with major trauma : : Prospective observational study / 
PY  - 2015///
CY  - Cairo : 
PB  - Emily Samir Mikhael Georgy , 
KW  - Interleukin-17
KW  - MODS
KW  - Polytrauma
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology; Issued also as CD
N2  - Background: Multiple organ dysfunction syndrome (MODS) is a systemic,  dysfunctional inflammatory response characterized with high mortality rate. The  Interleukin-17 (IL-17) family is generally regarded as a bridge system connecting  innate and adaptive immunity in induction and mediation of pro-inflammatory  responses.  Aim of work: The aim of the present study is to investigate association between IL- 17 and MODS in polytrauma patients as well as to test the clinical relevance of IL-17  single nucleotide polymorphism (rs1974226) in patients with major trauma. Results: IL-17 serum level was significantly increased (p=0.039) in group I versus  group II patients. As for the IL-17 genotyping, the present study revealed no  association (p=0.197) between IL-17 rs1974226 different genotypes and the  development of MODS. With regards to mortality, IL-17 serum level was  significantly higher (p =0.016) in patients who had a lethal outcome versus those who  survived. The ROC curve analysis showed that IL-17 can be a promising biomarker in  the prediction of MODS (AUC=0.721) in patients with polytrauma. Conclusion: IL-17 can be considered an important early biochemical marker for  predicting the development of MODS. On the other hand, IL-17 rs1974226 might not  be associated with the occurrence of MODS
UR  - http://172.23.153.220/th.pdf
ER  -