Effect of selenium, vitamin E, spirulina algae extract and sulfur containing amino acids on some biochemical parameters in streptozotocin diabetic rats /
تاثير السيلينيوم وفيتامين هـ ومستخلص طحلب السبيرولينا والأحماض الأمنية المحتوية على الكبريت على بعض القياسات البيوكيميائية فى الجرذان المصابة بالسكرى المستحدث بالاستريبتوزوتوسن
Doaa Mohamed Salah Ali Foda ; Supervised Sayed Mohamed Rawi , Iman Mourad Nasef , Ebtehal Kamal Farrag
- Cairo : Doaa Mohamed Salah Ali Foda , 2015
- 177 P. : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Zoology
Antioxidants are emerging as prophylactic and therapeutic agents that scavenge free radicals, reactive oxygen species and prevent their damaging effect in the cells of the body.In our study, the effect of oral supplementation of antioxidants (sodium selenate & vitamin E, Spirulina platensis algae whole extract and taurine was examined in streptozotocin induced diabetic rats. Pre- and post-treatments for each supplement were separately established in diabetic rats. A challenging group treated with the current anti-diabetic drug amaryl was introduced in our study for comparing results besides the diabetic non treated group and the frank control one. Some serum biochemical parameters were determined besides the immunological parameters in thymus and spleen. Also histological examinations of pancreas were investigated for showing the impact of treatments on diabetes progress in the stained pancreatic islets. Immunohistochemical assay was introduced on two glycolitic hormones; insulin and glucagon. Results showed that post-supplementions of all studied antioxidants showed a better improvement in almost all parameters under investigation