Mohamed Saeed Aiaty Sayed <br/><br/>
Cytoreductive surgery plus intraperitoneal hyperthermic chemotherapy for peritoneal carcinomatosis : Indications, technique and complications /  
  العلاج الجذري الجارحي للأوارم المنتشرة بالصفاق "الغشاء البريتوني" بالاضافة للعلاج بالتسخين الحراري للكيماوي و تدويره داخل التجويف البريتوني : الدواعي.. كيفية الاستخدام و المضاعفات :  
Mohamed Saeed Aiaty Sayed ; Supervised Wahid Yousry Gareer , Mustafa Mahmoud Elserafy , Mohamed Hany Elnagger 
 - Cairo :   Mohamed Saeed Aiaty Sayed ,   2015 
 - 161 P. :   facsimiles ;   25cm 
<br/><br/>Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of  Oncology (Surgical) 
<br/><br/> Aim of work. The purpose of our study was to evaluate the perioperative  complications, toxicity, mortality rates after cytoreductive surgery (CRS), and effects of hyperthermic intraperitoneal chemotherapy (HIPEC) used in  the treatment of peritoneal surface malignancies. At a single institution" National Cancer Institution" in Egypt. Results. Total of 51 procedures of CRS and HIPEC were performed on patients with, peritoneal carcinomatosis (PC) from different primary  cancer. The morbidity rate was 39.2% of all procedure, and grades I/II and  grades III/IV complications were 19.6 % and 19.6 %, respectively  according Common Terminology Criteria for Adverse Events (CTCAE). The most frequent complication was intestinal leakage including intestinal  fistula 35% (7/20) of total number of postoperative complications. The mortality rate was 5.8%, and reoperation was needed in 3.9 % of all procedures (2/51).Mortalities were in cases of anastomotic leakage were  required reoperation , first patient, to do ileostomy and burst abdomen for  closure and the second one to do closure of abdomen to repair burst  abdomen and debridement of wound sepsis. Multivariate analysis showed Operative time was the most significant  factor which increased the occurrence of postoperative complications. Operative time shows direct relationship with morbidity, the longer the  operative time, the more risk having morbid condition (P < 0.004). (One hour increase in operative length =increase 1.5 liability to have morbid condition. No signicant difference was observed among age, gender, PCI and origin of the primary tumor, and occurrence of toxicity and surgical complications. Prolonged operation times resulted in higher complication  and/or toxicity rates (P < 0.004).  
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<br/><br/><label>Subjects--Index Terms: </label>Cytoreductive surgery  Mesothelioma  Peritoneal carcinomatosis