TY  - BOOK
AU  - Heba Ali Abdelrahman Shalabi 
AU  - Abdelwahab A. Elghareeb , 
AU  - Alaa Abdelhamed Shamkh  , 
AU  - Sayed Fahim Tahaa , 
TI  - Teratogenic effects of bronchodilators drug on the pregnant female of albino rats and their offsprings / 
PY  - 2015///
CY  - Cairo : 
PB  - Heba Ali Abdelrahman Shalabi , 
KW  - Pregnant albino rats
KW  - Skeletal  malformation
KW  - Teratogenecity
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Zoology; Issued also as CD
N2  - The present study aimed to evaluate the teratogenic effects of the  mucolytic and broncholytic drug (Mucophylline) is daily oral  administered to the pregnant albino rats. The pregnant animals treated  during the gestational period (5th {u2013} 19th day of gestation) with doses  30.83 mg/Kg and 66.61 mg/Kg (human equivalent dose). On the 20th  day of gestation, the animals were sacrificed and the numbers of  implanation sites, resorbed and live fetuses were counted. The  placental weight, fetal weight, length and tail length were recorded.  The external morphology and skeletal malformations, histological  studies of placenta, brain, liver and kidney of mother and fetus were  evaluated. Also the oxidative stress markers were evaluated. Results  showed decreased weight gain, fetal growth retardation during  gestation period was dose dependent. Hematoma and anomalies of  limbs were detected morphologically in the fetuses of maternally  treated groups. Fetal skeletal abnormalities included lack of bones  ossification and bent ribs
UR  - http://172.23.153.220/th.pdf
ER  -