TY  - BOOK
AU  - Mennatallah Adel Gowayed 
AU  - Ahmed Sherif Attia  , 
AU  - Christoph Baerwald , 
AU  - Hanan Salah Eldin Elabhar , 
TI  - Comparative study of the anti-inflammatory effect of galantamine and leflunomide with emphasis on the potential mechanism(s) of action of galantamine in experimental adjuvant- induced arthritis in rats / 
PY  - 2015///
CY  - Cairo : 
PB  - Mennatallah Adel Gowayed , 
KW  - Galantamine
KW  - Induced arthritis
KW  - Leflunomide
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology; Issued also as CD
N2  - Aim of The work : In a study in the United States, ten patients with RA suffer chronic  fatigue syndrome to which they were treated with galantamine. Surprisingly,  galantamine improved also their symptoms of RA, where they experienced less  swollen and painful joints. Up till now, this AChEI is being used in AD patients  to directly enhance the acetylcholine-mediated neuronal transmission, however,  increasing evidences in the past few years pointed also to a possible anti- inflammatory role of these agents in AD treatment. Depending on these  coincidences, the aim of part I of this study was set to evaluate the anti- inflammatory effect of galantamine, and to compare its efficacy with the  conventional anti-rheumatic drug leflunomide, in the treatment of experimental  rheumatoid arthritis. Signs of inflammation and disease progression were  followed up during the experimental period. Pro-inflammatory (TNF-Ü) /anti- inflammatory (IL-10) cytokines, a chemokine (MCP-1), as well as a specific  serological marker for RA (anti-CCP) were evaluated in the serum of  experimental animals. Moreover, radiological pictures were taken, as being a  standard method for RA evaluation and therapeutic monitoring
UR  - http://172.23.153.220/th.pdf
ER  -