Elmahdi Abubaker Mahmmoud Abubaker  <br/><br/>
Synthesis and biological evaluation of some new heterocyclic compounds incorporating pyrrole moiety /  
 تشييد وتقييم النشاط البيولوجى لبعض المركبات غير متجانسة الحلقة الجديدة المحتوية على البترول  
Elmahdi Abubaker Mahmmoud Abubaker ; Supervised Sayed Mohamed Riyadh , Sobhy Mohamed Gomaa  
 - Cairo :   Elmahdi Abubaker Mahmmoud Abubaker ,   2015 
 - 128 P. ;   25cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry 
<br/><br/> A novel series of 2-ethylidenehydrazono-4-substituted-5- arylazothiazoles and 3-amino-5-arylazo-2,3-dihydrothiazoles was prepared by cyclocondensation of Ü-keto hydrazonoyl halides with ethylidenethiosemi-  carbazide and ethylidenethiocarbohydrazide, respectively. These cyclo- condensation reactions were achieved by using chitosan-grafted-poly- (vinylpyridine) as a novel basic catalyst. Also, reactions of ethylidenethiosemi-  carbazide or ethylidenethiocarbohydrazide with N-phenyl benzenecarbo- hydrazonoyl chlorides, bereft of Ü-keto group, using grafted-chitosan, proceeded with similar mechanism and afforded the same 1,3,4-thiadiazoles as  the end products. The structures of the newly synthesized compounds were  established on the basis of spectroscopic evidences and their alternative synthesis by other methods. Also, the molecular mechanics calculations were used to explain the stability of these stereoselective products. Moreover, the  selected newly synthesized products were evaluated for their anti-cancer activity against a colon carcinoma cell line (HCT-116) and liver carcinoma cell line  )HepG-2( and the results revealed promising activity  
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<br/><br/><label>Subjects--Index Terms: </label>Incorporating New  Heterocyclic Compounds  Pyrrole Moiety