TY  - BOOK
AU  - Rasha Mohamed Mohamed Hassan 
AU  - Kamilia Mahmoud Amin  , 
AU  - M. Nabil Youssef Aboul-Enein , 
TI  - Synthesis and anticonvulsant evaluation of some  substituted-1,3-diazaspiro decan-4-one derivatives  / 
PY  - 2015///
CY  - Cairo : 
PB  - Rasha Mohamed Mohamed Hassan , 
KW  - 1,3-diazaspiro
KW  - Anticonvulsant compounds
KW  - Decan-4-one derivatives
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry; Issued also as CD
N2  - The search for anticonvulsant compounds with selective activity and less toxicity continues to be  an area of intensive research in medicinal chemistry. Thus, in this work, the first part deals with  the synthesis of certain substituted spiroimidazolidinones (1,3-diazaspiro[4.5]decan-4-ones)  VIa-d and VIIIa-x and evaluation of their anticonvulsant properties. Also, in this part a  molecular modeling study was performed for the designed target compounds. Moreover, in the  second part, the enantioseparation of the racemic derivatives VIc-d and VIIIm-x using different  polysaccharide type chiral stationary phases (CSPs), namely, Chiralcel OJ, Chiralcel OD and  Lux {u2013}amylose-2 has been studied. Accordingly, this thesis is divided into two parts including the following sections:  A) Part I  Introduction:  This part includes the mechanism of action of antiepileptic drugs and a review on the different  biological activities of imidazolidines, imidazolidine-2-one and imidazolidine-4-one moieties as  well as their methods for synthesis.  Aim of the Present Work:  This section discusses the rationale on which the design of the synthesized compounds was  based, in addition to the schemes followed in their synthesis.  Theoretical Discussion:  This section addresses the reactions followed in the synthesis of the new target compounds VIa- d and VIIIa-x, in addition to intermediates needed in their preparation. The strategies followed  for the synthesis of the designed compounds, as well as starting materials and intermediates have  been described in Schemes I and II.
ER  -