Angiotensin-converting enzyme Insertion/deletion polymorphism In hospitalized infants and children with pneumonia /
حساب معدل تعدد الأشكال (حذف / إضافة) في الإنزيم المحول للأنجيوتنسين في مرضى الالتهاب الرئوي المقيمين داخل المستشفى
Mohamed Abdelfattah Mohamed ; Supervised Hala Hamdy Haaban , Nihal Mohamed Elrifai , Hanan Elhussieny Elwakel
- Cairo : Mohamed Abdelfattah Mohamed , 2015
- 123 P. : charts ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics
In the present case- control study, detection of Angiotensin Converting Enzyme (ACE) Polymorphism among admitted children suffering from community-acquired pneumonia (CAP) was performed to investigate the associationbetweenACE polymorphismand the risk and outcome of CAP. The study was conducted on 77 children with CAP and 73 healthy age- and sex- matched controls. Cases were subjected to a complete clinical study and investigations were performed: Complete Blood Count (CBC), chest x- ray (CXR), C - reactive protein (CRP), Erythrocytic Sedimentation Rate (ESR) in the first hour, and Angiotensin Converting Enzyme Insertion/Deletion (ACE I/D) Polymorphism using polymerase chain reaction (PCR). The study yielded the following results:The present study couldnt demonstrate a significant association between different types of ACE genotypes of ACE polymorphism in relation to pneumonia risk(P value >0.05).There was no statistically significant association between different genotypes of ACE polymorphismin pneumonia patients and outcome of pneumonia (oxygen need, ICU admission, need for mechanical ventilation, death & hospital stay more than 1 week) (P value >0.05). The study concludes that ACE polymorphismhas no significant relation to risk & outcome of pediatric pneumonia. Therefore, further studies in this topic should be conducted