Alaa Mahmoud Abdallah Abu Mahfouz <br/><br/>
Effect of grape seed extract on oxidative stress induced by argon laser beam during eye treatmen /  
 تأثير مستخلص بذور العنب على الاجهاد التأكسدى أثناء علاج العين بأشعة الليزر 
Alaa Mahmoud Abdallah Abu Mahfouz ; Supervised Maha Anwar Ali , Mona Mostafa Gamal 
 - Cairo :   Alaa Mahmoud Abdallah Abu Mahfouz ,   2015 
 - 118 P. :   photographs ;   25cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biophysics 
<br/><br/> Oxidative damage induced by Argon laser treatment (photocoagulation) can irreversibly damage the retina tissues. Retina is extremely rich in polyunsaturated lipids; this makes it particularly sensitive to reactive oxygen species (ROS). Grape seed proanthocyanidins extract (GSPE) is a widely consumed dietary supplement that has the capability to scavenge oxidants and free radicals and also it has low toxicity and no genotoxic potential. The present study investigated the protective effect of GSPE on ROS produced due to argon laser photocoagulation. Results showed that GSPE supplementation reduced malondialdehyde (MDA) and increased the total antioxidant capacity (TAC) in the ocular tissue, FT - IR results as well as histological findings showed a positive result for GSPE in reducing laser  effects on the retinal tissue. GSPE has an extremely beneficial role in overcoming the resultant adverse biological effects of argon laser  photocoagulation on retinal tissues, due to its potent antioxidant properties 
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<br/><br/><label>Subjects--Index Terms: </label>Grape seed extract Proanthocyanidins Retinal photocoagulation