Ahmed Abbass Mohamed Abdelrahman  <br/><br/>
Synthesis and biological evaluation of certain pyrazole derivatives /  
 تشييد و تقييم بيولوجى لبعض مركبات البيرازول  
Ahmed Abbass Mohamed Abdelrahman ; Supervised Fatma Abdelfattah Ragab , Yassin Mohammed Nissan Soliman  
 - Cairo :   Ahmed Abbass Mohamed Abdelrahman ,   2015 
 - 284 P. :   charts ;   25cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy  - Department of Pharmaceutical Chemistry 
<br/><br/> The present investigation deals with the semi-synthesis of certain 1,3,4- trisubstituted pyrazole derivatives derived from the natural furochromone khellin,  to be screened for their in vivo anti-inflammatory activity and ulcerogenic liability  hoping to obtain anti-inflammatory agents with high potency and lower side  effects. Furthermore, PGE₂ and TNFÜ immunoassay were carried out to determine  the percentage inhibition of these factors by the most active tested compounds.  Docking study was conducted for the tested compounds on the active site of  COX-2 enzyme to study the binding mode in the active site of the enzyme.The thesis consists of the following parts:  1.Introduction:   In this section, literature review about the various biological and  pharmacological activities especially the anti-inflammatory activity of pyrazole,  pyrazoline, benzofuran and chalcone derivatives was presented. Also, different  reported methods for the preparation of both pyrazole and pyrazoline nuclei were  described 
<br/><br/>
<br/><br/><label>Subjects--Index Terms: </label>Anti-inflammatory activity of pyrazole Certain pyrazole derivatives  Pyrazoles