TY  - BOOK
AU  - Yasser Ramadan Abdalwanees Hashad
AU  - Ahmad M. Farag  , 
AU  - Amr Saad Mohamed  , 
AU  - Enas Abdellateef  , 
TI  - Effect of genetic polymorphisms of CYP P450 and multidrug resistance 1 on cyclosporine after renal transplantation in Egyptian patients / 
PY  - 2015///
CY  - Cairo : 
PB  - Yasser Ramadan Abdalwanees Hashad , 
KW  - Cyclosporine
KW  - CYP3A4
KW  - Egyptian
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry; Issued also as CD
N2  - This study was conducted to to evaluate retrospectively the effects of  genetic polymorphisms of CYP3A4, CYP3A5 and MDR1 on cyclosporine trough and 2 hour s blood concentration during the early   period after renal transplantation in Egyptian patients. Forty two renal transplant recipients and forty eight healthy controls Egyptian subjects were genotyped by polymerase chain  reaction{u2013}restriction fragment length polymorphism for CYP3A4*18A, CYP3A5*3 and MDR1 C3435T. Cyclosporine C₀ and C₂ whole  blood levels were measured. The frequency of the CYP3A4*18A,  CYP3A5*3 and MDR1 C3435T variant alleles in all subjects were  0.006, 0.865 and 0.344 , respectively,comparison of the CsA levels  between patients with CYP3A5 3*/3* genotype and those with  1*/1* genotype, showed that all levels of C₀ and C₂ are higher in 3*/3* genotype than that of 1*/1* genotype but without significant differences between the two groups at day-7 C₀ (P = 0.25), day-30 C₀ (p = 0.28), day-90 C₀ (p = 0.3) and at day-30 C₂ (P = 0.64)
UR  - http://172.23.153.220/th.pdf
ER  -