Serum and tissue 2HVEM3 levels in patients with multiple or recurrent verruca vulgaris /
مستوى مادة "الهيفم " في المصل والجلد للمرضى المصابين بالثآليل الفيروسية المتعددة أو المتكررة
Marwa Abdelghany Mansour ; Supervised Manal A-W Bosseila , Olfat G. Shaker , Dina M. Kadry
- Cairo : Marwa Abdelghany Mansour , 2015
- 114 P. : charts ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venereology
Warts are benign lesions caused by human papilloma virus (HPV). Host defense against HPV relies on intact and functioning cellular immunity including T cell and natural killer (NK) cell cytotoxicity. Therefore, in patients in whom warts are severe, concern for immune defects is raised. HVEM (herpes virus entry mediator) is a member of the tumour-necrosis factor receptor family. It has diverse functions, augmenting or inhibiting the immune response. It acts as a receptor to enhance immune responses through binding LIGHT or LTalpha which signaling is important for cell survival, inflammation, and tumor eradication. Aim of work: To identify the role of cell-mediated immunity, expressed as HVEM level, in cases of multiple/recurrent verrucae, in order to assess its role in the adaptive immune response to HPV