TY  - BOOK
AU  - Marwa Nagi Ramadan Elfiki 
AU  - Amaal Abdo Abdelaal , 
AU  - Faten Mohamed Tharwat Elshanawani , 
AU  - Ola Abdelmonaem Elsesy , 
TI  - The association between the ras  association domain family 1 isoform a  polymorphism and hepatocellular carcinoma in an Egyptian population / 
PY  - 2015///
CY  - Cairo : 
PB  - Marwa Nagi Ramadan Elfiki , 
KW  - Egyptian population
KW  - Hepatocellular carcinoma-
KW  - RASSF1A Ala133Ser genotypes
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology; Issued also as CD
N2  - Background: Hepatocellular carcinoma (HCC) is the sixth most common  cancer worldwide. Because of its high fatality rates, the incidence and  mortality rate are approximately equal. Thus, the pathogenesis of liver  diseases has been extensively studied focusing on genetic factors which  have a major role. One of these genetic factors is suppressor gene  RASSF1A, particularly single nucleotide polymorphism in RASSF1A  gene called Ala133Ser (rs2073498).  Objective: To study if Ala133Ser polymorphism of the RASSF1A gene  is associated with increased risk of HCC in Egyptian population.  Methods: The study included 50 patients with HCC and 50 healthy  subjects. They were subjected to genotyping for RASSF1A gene  Ala133Ser polymorphism using Restriction fragment length  polymorphism (RFLP) technique.  Results: (Ala/Ser+ Ser/Ser) genotype frequency was significantly higher  in HCC patients as compared to healthy subjects (P=0.000); also Ser  allele frequency was significantly higher in HCC patients as compared to  healthy subjects [OR 1.86, 95% CI (1.008-3.432)]( P= 0.032).  Conclusion: The results of this study may suggest a role of RASSF1A  gene Ala133Ser polymorphisms in HCC in Egyptian population.
ER  -