TY  - BOOK
AU  - Ahmed Mohamed Siddiq
AU  - Ayman Saied Soliman , 
AU  - Mohamed Alsayed Saleh , 
AU  - Nahed Salah Eldin Mohamed , 
TI  - Effects of }-3 fatty acids and estrogen replacement therapy on ovariectomy induced osteoporosis in female albino rats / 
PY  - 2016///
CY  - Cairo : 
PB  - Ahmed Mohamed Siddiq , 
KW  - Bone mineral density
KW  - Omega 3 fatty acids
KW  - Osteoporosis
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Physiology; Issued also as CD
N2  - Fatty acids especially omega 3 unsaturated fatty acids has known anti-inflammatory effects. And there are different mechanisms by which dietary fatty acids may affect bone, but there protective effect against postmenopausal osteoporosis remains a controversial issue. This study was applied on 50 female albino rats that were divided into 5 equal groups: sham operated group, ovariectomy group,  ovariectomy + flaxseed oil group (0.4 g per day),  ovariectomy + fish oil administered group (0.4 g per day)  and  ovariectomy + estrogen replacement therapy group (30 æg/kg 5 days a week). The study proceeded for 12 weeks then femurs bone mineral density (BMD) were measured with dual-energy X-ray absorptiometer (DXA) scan and serum osteoprotogerin (OPG), bone specific alkaline phosphatase (ALP-b) and tumour necrosis factor alpha (TNF-Ü) were measured.  There was a significant increase in the BMD of the treated groups compared with the ovariectomy group (p < .01). There were a significant differences in  the means of serum bone markers measures of the treated groups versus the ovariectomy group in the form of significant increase in OPG (p < .001) and a significant decrease in ALP-b (p < .001) and TNF-Ü (p < .001) of the treated groups compared with the ovariectomy group. This study showed a significant negative correlation between BMD and ALP-b (r = - 0.375, p < .001). According to this study the chronic administration of omega 3 fatty acids (flaxseed oil - fish oil) has a preventive effect against osteoporosis and suppression  of bone turn over process appears to have a role in this preventive effect
UR  - http://172.23.153.220/th.pdf
ER  -