Mona Ahmed Gamal Eldein Teleb <br/><br/>
Synthesis and cytotoxic activity of certain benzopyrone derivatives /  
 تشييد بعض مشتقات البينزوبيرون كمضادات للسرطان  
Mona Ahmed Gamal Eldein Teleb ; Supervised Fatma A. Ragab , Amal A. M Eissa , Samar Hashem Fahem 
 - Cairo :   Mona Ahmed Gamal Eldein Teleb ,   2016 
 - 123 P. :   charts , facsimiles ;   25cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry 
<br/><br/> Cancer is the biggest killer of our lives, so there is steadily increasing research in the field of anticancer therapy over recent years. However, lack of selectivity of chemotherapeutic agents against cancerous cells is still a significant problem with the current chemotherapy. Thus, in this study, the thirty new coumarin derivatives were synthesized and tested for their in vitro cytotoxic activity against MCF-7 breast cancer cell line. The most active derivatives were further tested against 4 different cell lines (HCT-116, HepG-2, A549 and SGC-7901 cell lines). In vitro EGFR inhibition in human breast cancer cell line MCF-7 was carried also for the most active 6 compounds. Furthermore, docking studies were undertaken for some compounds to gain insight into the possible binding mode of these compounds with the binding site of EGFR enzyme which is involved in cell survival and proliferation  
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<br/><br/><label>Subjects--Index Terms: </label>Benzopyrone Cancer  Synthesis and cytotoxic activity