Afaf Mohammad Mahmoud <br/><br/>
Micafungin as a prophylactic antifungal during induction phase of chemotherapy for pediatric acute lymphoblastic leukemia /  
 للوقاية من الاصابة بالفطريات خلال الفترة التحفيزية من علاج سرطان الدم الليمفاوى الحاد فى الاطفال Micafungin استخدام عقار المايكافنجين  
Afaf Mohammad Mahmoud ; Supervised Lobna Mohamed Shalaby , Hadir Ahmad Elmahallawy , Sahar Ahmad Khalil  
 - Cairo :   Afaf Mohammad Mahmoud ,   2016 
 - 89 P. ;   25cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - National Cancer Institute - Department of Pediatric Oncology 
<br/><br/> Background:  Invasive fungal infection (IFI) remains a major cause of infectious morbidity  and mortality in neutropenic patients receiving chemotherapy or hematopoietic  stem cell transplantation (HSCT). Micafungin exhibits broad antifungal activity  against both Aspergillus and Candida species.  Objective:  We performed a prospective study to determine the efficacy, safety, and  tolerability of prophylactic micafungin against IFI in pediatric neutropenic  patients during induction chemotherapy for acute lymphoblastic leukemia  (ALL). Results:  Treatment success rate, defined as absence of proven, probable, or possible  IFIs, was 75%. No adverse events were observed that could be related to  micafungin prophylaxis.  Conclusions:  These results suggest that prophylactic micafungin is well tolerated and may  prevent IFIs in pediatric patients with neutropenia receiving chemotherapy   
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<br/><br/><label>Subjects--Index Terms: </label>ALL  Induction chemotherapy  Pediatric