TY  - BOOK
AU  - Eman Galal Nouman
AU  - Hayam Mahmoud Lotfy , 
AU  - Medhat Ahmed Alghobashy , 
TI  - Analysis of some imidazole ring containing drugs / 
PY  - 2016///
CY  - Cairo : 
PB  - Eman Galal Nouman , 
KW  - Butoconazole
KW  - Dabigatran
KW  - Fenticonazole
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry; Issued also as CD
N2  - This thesis is concerned with the analysis of three selected drugs containing imidazole  ring namely, dabigatran etexilate, fenticonazole nitrate, and butoconazole nitrate.  In this work, different analytical techniques were applied for stability indicating  determination of dabigatran etexilate, in its pharmaceutical preparations using  spectrophotometric methods, densitometric and liquid chromatographic method.  LC-MSMS method was developed for determination of dabigatran etexilate and  its active metabolites, dabigatran and dabigatran o-glucuronide in human plasma.  Stability of fenticonazole nitrate was studied and stability indicating HPLC  method was developed and applied for simultaneous determination of fenticonazole  nitrate, methyl and propyl parabens in their laboratory prepared mixtures and in their  pharmaceutical preparation. Accelerated stability study and pre-formulation studies  were carried out on fenticonazole in cream dosage form.  Stability of butoconazole nitrate was studied and stability indicating UPLC  method was developed and applied for simultaneous determination of butonazole  nitrate, methyl and propyl parabens in their laboratory prepared mixtures and in their  pharmaceutical preparation.  LC-MSMS method was developed and validated for sensitive determination of  butoconazole in human plasma
UR  - http://172.23.153.220/th.pdf
ER  -