Mitochondrial DNA mutations and hepatocellular carcinoma /
ارتباط نسبة الفوليك اسيد بتحور الحامض النووي في ميتوكوندريا الخلايا الليمفاويه و ظهور سرطان الكبد الاولي
Ramy Saeed Amer ; Supervised Hosny Mohamed Salama , Eman Medhat Hasan , Abdelrahman Nabawy Zekry
- Cairo : Ramy Saeed Amer , 2016
- 131 P. : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Tropical Medicine
HCC is the most common primary malignancy of the liver. Diagnosis of HCC at early stages is crucial for potentially curative therapies. Mitochondrial (mt) DNA deletions and low folate status proposed characteristics of carcinogenesis. This study aims to evaluate folate related lymphocytic mt DNA deletions for early diagnosis of hepatocellular carcinoma. We also explored the relation between folate related lymphocytic mt DNA deletions and the clinic pathological features of HCC patients as well as its prognostic value