Effects of low flow sevoflurane versus low flow desflurane anesthesia on hepatic and renal functions in hepatitis C positive (Child A) patients undergoing laparoscopic cholecystectomy surgery /
دراسة مقارنة بين تأثير كل من سيفوفلورين و ديسفلورين على وظائف الكبد ومستوى فيروس سى و وظائف الكلى
Abdulrahman Mohamed Naguib Abou-Seada ; Supervised Hala Moustafa Goma'a , Khalda Galal Radwan , Bassant Mohamed Abdulhameed
- Cairo : Abdulrahman Mohamed Naguib Abouseada , 2016
- 95 P. : charts ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Anaesthesia
A prospective randomized control study with 68 patients (Child A) (D, n = 34 and S, n = 34). Liver and kidney function tests, plasma alpha Glutathione-S-transferase (Ü-GST), total 24 hours urinary microalbumin and realtime PCR HCV-RNA were assayed. Results: Preoperative and 3rd day postoperatively with S vs D respectively Ü-GST (4.98±1.97 vs 4.27±1.95 ng/ml non statistically significant)and (7.55±2.4 vs 9.48±1.87 ng/ml P = 0.001), HCV-RNA (4.63±0.86 vs 4.35±1.47 log non statistically significant) and (4.52±0.81 vs 4.69±1.22 log P=0.384) and total 24 hours urinary microalbumin (6.36±2.29 vs 6.90±2.97 mg/24 hours non statistically significant) and (55.67±22.67 vs 13.75±9.10 mg/24 hours P=0.001), yet theres a statistical significant between results pre and 3rd day post operatively for Ü-GST, HCV-RNA and total 24 hours urinary microalbumin, the only clinical significance was in total 24 hours urinary microalbumin which showed slight microalbuminurea with group S in the 3rd day post operatively. No clinical difference between preoperatively and post-operatively regarding hepatic and renal functions.Conclusion: Slightly better results in every parameter except for microalbuminurea with S. Neither S nor D were clinically superior to the other with respect to liver, kidneys functions and none of them affected the HCV-RNA virus load