TY  - BOOK
AU  - Yasmine Mohamed Gaber Murad
AU  - Ayman Mohamed Rashad Amer , 
AU  - Dalia Abdelhamid Omran , 
AU  - Mahasen Abdelrahman mabrouk , 
TI  - Role of acoustic radiation force impulse (ARFI) As noninvasive diagnostic tool in focal hepatic lesions / 
PY  - 2016///
CY  - Cairo : 
PB  - Yasmine Mohamed Gaber Murad , 
KW  - Acoustic radiation force impulse (ARFI)
KW  - Focal hepatic lesions (FHLs)
KW  - Hepatocellular carcinoma (HCC)
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Tropical Medicine; Issued also as CD
N2  - Background: Diagnosis of focal hepatic lesions ( FHLs) by modern imaging expose the patients to risks of contrast medium-induced side effects and irradiation hazards. Acoustic Radiation Force Impulse (ARFI) represents a new imaging method able to non-invasively assess the elastic properties of target tissues.Aim Of The Work: This study was designed to assess the validity of ARFI elastography as a non-invasive method for characterization of FHLs especially hepatocellular carcinoma (HCC). Methods: We enrolled 170 participants in the study, 120 patients with FHLs {uFD3E}88 HCC, 13 hemangioma, 13 metastatic, 6 other lesions), 30 patients with liver cirrhosis and 20 person as normal control groups. Patients were subjected to: Demographic, clinical, laboratory tests, abdominal ultrasound, triphasic CT or MRI, liver biopsy in some patients, stiffness of FHLs and liver parenchyma were measured by ARFI.  Results: Of 120 patients with FHLs (77.3 % of HCC group were males, with mean age 59.4± 8 years. Among non- HCC group, 50% were males with mean age 49.7±11 years), a Cut off value of 2.59 m/s of liver stiffness (LS) measured by ARFI can predict occurrence of HCC in cirrhotic patients, sensitivity 78.4% and specificity 72%. For liver tumors, the mean stiffness values were 2.2± 0.7m/s for HCC (n=76), 1.96± 0.7 m/s for hemangioma (n=12), and 2.87± 1.07 m/s for metastasis (n=8). Concluson: ARFI could non-invasively provide significant information regarding the tissue stiffness, useful for predicting HCC occurrence in cirrhotic patients and differentiating HCC from metastases and hemangioma from metastases
ER  -