TY  - BOOK
AU  - Samar Kamel Mohamed Khalil
AU  - Adel Mohamed AbuElfetouh Elbehairy , 
AU  - Hassan Abdelhalim Hassan Amer , 
AU  - Mohamad Ali Ahmed Warda , 
TI  - Some biochemical studies on immune response of chronic kidney disease patients / 
PY  - 2016///
CY  - Cairo : 
PB  - Samar Kamel Mohamed Khalil , 
KW  - Erythropoietin resistance
KW  - Inflammatory markers
KW  - Oxidative stress
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Veterinary Medicine - Department of Biochemistry and Chemistry of Nutrition; Issued also as CD
N2  - Inflammation and oxidative stress are two faces of one coin in end stage renal disease patients (ESRD) on maintenance hemodialysis. Their interconnection induces anemia complicated with erythropoietin hyporesponsiveness. The biochemical basis behind the resistance to erythropoietin therapy with frequent hemoglobinemia, oxidative stress and iron status have not been fully recovered. Two equal groups (40 patients each) of responders and non-responders to recombinant human erythropoietin therapy (higher than 300 IU / kg / wk of epoetin) were used in the study. Hematological and biochemical analysis of collecting blood and serum samples were performed along with serum electrophoretic protein foot printing. The leukocytes DNA fragmentation was used to evaluate the degree of oxidative insult. Erythropoietin (EPO) good responders showed lower erythrocyte malondialdehyde (E-MDA) level; less pronounced DNA fragmentation of circulating leukocytes than poor responder with elevated hemoglobin, albumin, A / G ratio, total iron, and ferritin levels. Contrariwise, lower erythrocyte superoxide dismutase (E-SOD) and catalase activities in EPO poor responder group than good responder one
ER  -