TY  - BOOK
AU  - Wallaa Abdelfattah Osman
AU  - Dina Ahmed Aly Labib , 
AU  - Elsayed Mahmoud Elrokh , 
AU  - Mona Osman Abdelhalim , 
TI  - Comparative study of the analgesic, anti- pyretic and anti- inflammatory activities of extra virgin olive oil and ibuprofen and Their combination in different animal models in albino mice / 
PY  - 2016///
CY  - Cairo : 
PB  - Wallaa Abdelfattah Osman , 
KW  - Anti-inflammatory
KW  - Anti-pyretic
KW  - EVOO
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pharmacology; Issued also as CD
N2  - Background: Inflammation is a complex series of physiological events designed to repair the  damaged tissue caused by injury or infection. It is involved in the development of many  diseases. Cardinal signs of inflammation as pain and fever are commonly treated with  NSAIDs which have many adverse effects. Recently, there is a new trend towards the natural  dietary anti-inflammatory agents which have potential therapeutic effects with less adverse  events. Extra virgin olive oil (EVOO) has been documented nowadays to have diverse  beneficial effects on human beings. Oleocanthal is a phenolic compound in olive oil which was proved to have similarity with ibuprofen (IBU). Aim of the work: This work was designed to compare the analgesic, antipyretic and anti- inflammatory effects of EVOO with IBU and their combinations on different animal models  in mice. Result: The results revealed that the group treated with the combination of EVOO with the therapeutic dose of IBU 100mg/kg showed the highest percentage of inhibition in acetic acid- induced writhing test and in carrageenan-induced paw edema and the lowest rectal temperature in the brewer's yeast induced pyrexia, followed by that using the standard treatment IBU (100mg/kg) separately. Meanwhile, using EVOO alone or in combination with  the low dose of IBU (40mg/kg) showed significant results from the disease model (positive control) but their effects were less than the group treated with the standard drug (IBU 100mg/kg). In the carrageenan induced peritonitis, the results revealed that using the  combination of EVOO either with the therapeutic dose of IBU (100mg/kg) or with its low dose (40mg/kg) showed the best results in a dose dependent manner, while using olive oil  alone decreased significantly most of the measured parameters and its effects was insignificant from the standard treatment IBU (100mg/kg)
UR  - http://172.23.153.220/th.pdf
ER  -