Radwa Ezzat Amin Mohamed <br/><br/>
Periostin as a systemic biomarker of eosinophilic airway inflammation in asthmatic children /  
 البيريوستين كعلامة بيولوجية حيوية لدى الاطفال المصابين بالربو الشعبى  
Radwa Ezzat Amin Mohamed ; Supervised Hala Hamdy Shaaban , Hanan Mohsen Osman , Salma Mohamed Said 
 - Cairo :   Radwa Ezzat Amin Mohamed ,   2016 
 - 135 P. :   charts , facsimiles ;   25cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics 
<br/><br/> Th2_eosinophilic inflammation has been considered to be the  dominant inflammatory pattern in asthma. Eosinophilic disease is a strong  predictor of corticosteroid responsiveness. Direct airway sampling is  technically challenging and impractical.Serum periostin may be a  biomarker of eosinophilic asthma and it may help in asthma stratification  prior to therapeutic interventions.The aim of this study is to explore  serum Periostin as potential systemic biomarker in eosinophilic asthma in  children and to correlate it with type of asthma.  Subjects and methods:  This is a cross sectional study, 60 asthmatic children with varying  degree of severity, aged from 1-12 years were recruited from allergy and  pulmonology clinic at Abo El Rish children's hospital, Cairo University  and studied in comparison to 20 healthy age and sex matched children.  Serum periostin level and complete blood picture including absolute  eosinophilic count are measured in both asthmatics and controls.  Results:  Serum periostin levelis higher in asthmatic children compared to  controls with with p-value <0.001, Serumperiostinlevel was significantly  higher in severe asthmatics inspite maximum ICS compared to mild- moderate asthmatics with p-value<0.0001.There is positive correlation  between serum periostin level and degree of severity of asthma with p- value<0.0001. Serum periostin level has highest value in allergic rhinitis  compared to allergic conjunctivitis and eczema, no significant correlation  was found between periostin level and patients with positive family  history of atopy p-value=0.187.  Conclusion:  These findings imply that serum periostin level may be involved in  the pathogenesis of eosinophilic asthma. Serum level of periostin as a  biomarker has the potential to be used as noninvasive inflammatory  markers for evaluation of airway inflammation in asthma 
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<br/><br/><label>Subjects--Index Terms: </label>Asthmatic children Biomarkers-periostin Bronchial asthma