TY  - BOOK
AU  - Ayman Yousry Ali Elhadaky
AU  - Attia Hassan Atta  , 
AU  - Hassan Elsayed Abdou Elmetwaly , 
TI  - Pharmacokinetics of cefquinome in normal and diseased camels / 
PY  - 2016///
CY  - Cairo : 
PB  - Ayman Yousry Ali Elhadaky , 
KW  -  LC-MS/MS
KW  -  Pharmacokinetics
KW  - Cefquinome
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Veterinary Pharmacology; Issued also as CD
N2  - The aim of this work is to evaluate the pharmacokinetics of cefquinome in camels and to compare its  pharmacokinetics in apparently healthy and Trypanosoma evansi infected camels. A single dose of  cefquinome was administered intravenously and intramuscularly at 1 mg/kg to two groups of camels with a 30 days washout period in-between. Group (1) included five normal she-camels and Group (2): included  five Trypanosoma evansi naturally infected she-camels. Plasma concentrations of cefquinome were determined by HPLC-MS/MS assay. Cefquinome concentration vs. time data after IV and IM was best fitted  to a two-compartment open model in normal and infected camels. Cefquinome mean values of area under concentration{u2013}time curve (AUC) were 15.37±1.06 og/ml.h for IV dose and 12.85±2.15 og/ml.h for IM dose. Distribution half-lives and elimination half-lives after IV dose were 0.14±0.04 h and 3.15±0.22 h and  1.42±0.11 h and 6.68±0.87 h for IM dose. The values of total body clearance (Cl ) and volume of tot distribution at steady state (V ) were 0.07±0 L/kg/h and 0.27±0.02 l/kg, respectively following intravenous ss injection. Following a single intramuscular injection of 1 mg cefquinome /kg.b.wt. in normal camels, The  pharmacokinetics parameter revealed that the maximum serum concentration (C ) was 3.2±0.39 æg/ml   max reached at maximum time (T ) at about 0.82±0.06 h, the absorption half-life [t ] was 0.26±0.03 hours, max 1/2ab the elimination half-life t was 6.68±0.87hours and bioavailability of 85.52±11.09 %. The present study 1/2Ý  recommended that the intravenous and intramuscular injection of cefquinome is effective against, Streptococcus spp., staphylococci, Klebsiella spp., Pasteurella spp., Salmonella spp., enteric and systemic  Escherichia coli. at a dose rate of 1mg/kg twice daily for the normal and the naturally infected camels with  Trypanosoma evansi, which did not suffer from fever or parasitaemia
ER  -