Spectrophotometric determination of the psychiatric drug melatonin in the pure form and in different pharmaceutical preparations /
التقدير الطيفى للميلاتونين كدواء مؤثر على الحالة النفسية فى الصورة النقية وفى المستحضرات الصيدلانية المختلفة
Abanoub Mosaad Abdallah ; Supervised Maher Mohamed Hamed , Mohamed Mahmoud Abdou , Marwa Elbadry Mohamed
- Cairo : Abanoub Mosaad Abdallah , 2016
- 160 P. : charts , facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Analytical Chemistry
This work has been carried out to investigate the: Spectrophotometric determination of the psychoactive drug melatonin in its pure form and different pharmaceutical preparation via charge transfer reaction formation with the s- acceptor 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) and also via oxidation-reduction reaction with Fe(III) solution by using potassium ferricyanide (K [FeIII(CN) ]) reagent. 3 6 2- Elucidation of the chemical structure of the formed charge transfer complex via elemental analysis, IR, 1H NMR and mass spectra . Studying the thermal properties of the formed complex and calculation of its kinetic thermodynamic parameters and studying some of its bioactivity. Carrying out of Density Functional Theory (DFT) and Time- Dependent Density Functional Theory (TD-DFT) calculations for the formed complex