Electrochemical sensors based on carbon paste modified electrode for drugs /
حساسات كهروكيميائية تعتمد على قطب عجينة الكربون المعدل للأدوية
Asmaa Hamdy Ibrahim ; Supervised Nada Farouk Ahmed , Shereen Musa Azab
- Cairo : Asmaa Hamdy Ibrahim , 2016
- 130P. : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Physical Chemistry
A novel and sensitive electrochemical sensor for the determination of some catecholamine neurotransmitters of interest as well as drugs in 0.04 M universal buffer solution (pH 7.4) is introduced using carbon paste electrode modified with ionic liquid crystal (1-Butyl-1-methylpiperidinium hexafluorophosphate) in presence of sodium dodecyl sulfate (SDS). Also Nickel Oxide Nanoparticles have been introduced to this modified electrode to investigate the drugs and neurotransmitters. The effect of various experimental parameters including pH and scan rate was investigated. This sensor modified electrode is selective for the determination of the neurotransmitters and the drugs in presence of interference molecules such as uric acid and ascorbic acid. The designed sensor showed good reproducibility, high stability, sensitivity and anti- interference ability. The sensor was further utilized to determine neurotransmitters and drugs level in human urine and satisfactory results are obtained with low detection limit