TY  - BOOK
AU  - Nehad Samir Ali
AU  - Abdelhamid Hashem Hashem Abdelhamid , 
AU  - Akmal Mostafa Kamal Hassan , 
AU  - Alia Adel Abdelfattah Saleh , 
TI  - Serum interleukin 6 and its relation to cognitive functions in elderly patients with early onset depression  / 
PY  - 2016///
CY  - Cairo : 
PB  - Nehad Samir Ali , 
KW  - Cognitive functions
KW  - Early Onset Depression
KW  - Interleukin 6
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Neuropsychiatry; Issued also as CD
N2  - Advancing age is known to be associated with disruption of homeostasis in the immune system. Although the effects of aging on  immune function are poorly understood, the aging brain has been  characterized by a shift in the homeostatic balance of inflammatory mediators observed in mid-adulthood .In the last decade, a body of evidence has consistently demonstrated an association between major depressive disorder (MDD) and cognitive impairment in elderly, especially in the domains of  attention, working memory, and executive functions. Additionally, Immune status has also been associated with major depressive disorder (MDD) relative to healthy individuals. When the release of inflammatory cytokines is excessive or sustained, the inflammatory mediators  predominantly, IL 6, have neurotoxic effects on neurons and glial cells.The effect of this immunologic shift on cognitive performance is unclear. Some longitudinal studies have indicated a relationship between high cytokine levels, e.g., interleukin-6 (IL-6) and C-reactive protein (CRP), in peripheral plasma and development of multiple forms of dementia
UR  - http://172.23.153.220/th.pdf
ER  -