TY  - BOOK
AU  - Rabab Radi Gomaa Mahmoud
AU  - Hanan Hassan Mohammed , 
AU  - Rasha Ahmed Khairy , 
AU  - Solafa Ameen Alabyad , 
TI  - Evaluation of survivin expression in breast cancer : : Histopathological and immunohistochemical study / 
PY  - 2016///
CY  - Cairo : 
PB  - Rabab Radi Gomaa Mahmoud , 
KW  - Apoptosis
KW  - Breast cancer
KW  - Immunohistochemistery
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pathology; Issued also as CD
N2  - Background: Breast cancer (BC) is the most common type of cancer among women world-wide and leading cause of cancer related deaths. As normal breast development is controlled by a balance between cell proliferation and apoptosis, and there is also strong evidence that tumor growth is not just a result of uncontrolled proliferation but also of reduced apoptosis. Tumor cells can acquire resistance to apoptosis by expression of certain anti {u2013} apoptopic proteins called Inhibitors of Apoptosis Proteins (IAP). Survivin is the smallest IAP family member and has a dual activity as both an inhibitor of apoptosis and regulator of cell cycle. Objectives: Investigation of immunohistochemical expression of survivin in cases of female BC and correlation of this expression with the clinico-pathological aspects of the tumors. Materials and methods: Fifty formalin fixed paraffin embedded BC tissue sections were randomly collected. All the available data were collected from the patients{u2019} reports. The paraffin blocks were sectioned and stained with hematoxylin & eosin stains for histologic evaluation. Additional sections were immunostained with survivin. Results: Nuclear survivin expression was detected in 66% of cases and it was associated with some of the negative prognostic factors although it didn't reach statistical significance (p-values were found to be higher than 0.05) where higher rate of survivin expression showed apparent direct association with IDC-NST histologic type, presence of insitu component, ER and PR negativity and high Ki-67 proliferation index as well as Her 2 enriched molecular subtype. Conclusion: Survivin expression is detected in 66% of breast carcinoma cases and is likely to be associated with poor prognosis making it a potential target for treatment
ER  -