Outcome of relapsing acute lymphoblastic leukemia in children at the National Cancer Institute, Egypt /
نتائج انتكاس سرطان الدم الليمفاوى الحاد للأطفال بالمعهد القومى للأورام
Mohamed Ahmed Elnakeeb ; Supervised Iman Abdelmokhales Sidhom , Ahmed Mohamed Kamel , Eman Zaghloul Kandeel
- Cairo : Mohamed Ahmed Elnakeeb , 2016
- 111 P. : charts ; 25cm
Thesis (M.Sc.) - Cairo University - National Cancer Institute - Department of Pediatric Oncology
Greater than 80% of children diagnosed with acute lymphoblastic leukemia (ALL) are expected to become long-term survivors. Despite this impressive accomplishment, around 20% of children ultimately relapse. Our aim was to assess the outcome and pattern of relapse among ALL pediatric patients at the national cancer institute, Cairo university. This is a retrospective analysis over a 4-year period extending from January 2008 to December 2011, which included a total of 291 patients with a diagnosis of ALL. Thirty-three out of 239 patients (13.8%) relapsed with a diagnosis of ALL. Regarding initial patient characteristics, initial total leucocytic count and risk stratification were found to be statistically significant for risk of relapse (p-values, 0.018 and 0.03 respectively). Fourteen patients (42.4%) had isolated CNS relapse, 18 (54.5%) patients had hematological relapse and only 1 (3.1%) patient had a combined relapse. Fifteen patients (45.4%) had very early relapse, 13 (39.3%) patients had early relapse and 5 (15.1%) patients had a late relapse. Second complete remission (CR2) rates were much better for early and late relapse than those with a very early relapse 84.6% and 80% respectively, versus 33.3%, p-value 0.018. Mortality was 84.8% 28 out of 33 patients
Acute lymphoblastic leukemia Children National Cancer Institute, Egypt