TY  - BOOK
AU  - Mohamed Ahmed Mohamed Naeem
AU  - Amina Abdelsalam Mahmoud , 
AU  - Hoda Mostafa Yassen Elazizy , 
AU  - Mohamed Hesham Safouh  , 
TI  - Oxidants and antioxidants status and Viral Hepatitis C infection among patients with Sickle Cell Diseas / 
PY  - 2016///
CY  - Cairo : 
PB  - Mohamed Ahmed Mohamed Naeem , 
KW  - Antioxidants
KW  - Catalase
KW  - Paraoxonase
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics; Issued also as CD
N2  - Objectives: The present study was conducted to evaluate the oxidant- antioxidant status of SCD patients and to study the impact of HCV sero- positivity on the oxidant-antioxidant status among SCD patients  Methods: The serum levels of total antioxidant(TAO), paraoxonase (PON), catalase(CAT) and malondialdehyde(MDA) were estimated in  50 patients with established diagnosis of SCA in steady state disease (21  males and 29 females) and 30 apparently healthy subjects age & sex  matched controls.  Results: Mean serum MDA and CAT in SCD cases were significantly  higher (P= 0.001; 0.01 respectively) while mean TAO, and PON1 levels  were significantly lower among SCD cases compared to controls (p=0.001). No significant differences in mean levels of CAT, PON, TAO and MDA in SCD males when compared with SCD females (P{u02C3} 0.05).  But we found that mean MDA in males was significantly lower than  females (P=0.03). No significant differences in the mean levels of CAT,  PON, TAO and MDA between HCV positive and HCV negative SCD patients (P{u02C3} 0.05). No significant differences in the mean levels of CAT, PON, TAO and MDA in SCD cases on hydroxyurea (HU) and those not  receiving HU (P{u02C3} 0.05). No significant correlations were detected  between CAT, PON, TAO, MDA and different patient variables (P{u02C3}  0.05).Conclusions: Oxidative stress is evident in SCD patients of both genders. HCV seropositivity or HCV-RNA positivity had no evidence of a more severe oxidative stress. Hydroxyurea did not play a significant role as an  antioxidant among our patients
ER  -