TY  - BOOK
AU  - Alaa saad Abdelhamid 
AU  - Mohammed Mahmud Abdellah Ali , 
AU  - Mona Salah Eldin Abdelmagid , 
AU  - Samia Mohammed Mohamed Gabal , 
TI  - CD147 Expression in non-invasive and invasive breast carcinoma and its correlation with  clinicopathological characteristics of these tumors immuohistochemical & histopathological study / 
PY  - 2016///
CY  - Cairo : 
PB  - Alaa saad Abdelhamid , 
KW  - Breast cancer
KW  - EMMPRIN
KW  - Non-invasive and invasive  ductal carcinomas
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pathology; Issued also as CD
N2  - Background: Breast cancer (BC) is the most common type of cancer among  women world-wide and leading cause of cancer related deaths. Distant  metastasesare responsible for the majority of cancer-related deaths.  Basigin (BSG) also known as extracellular matrix metalloproteinase  inducer (EMMPRIN) or cluster of differentiation 147 (CD147) is  a protein that in humans is encoded by the BSG gene. Basigin is a member  of the immunoglobulin superfamily, with a structure related to the putative  primordial form of the family. As members of the immunoglobulin  superfamily play fundamental roles in intercellular recognition involved in  various immunologic phenomena, differentiation, and development, basigin  is thought also to play a role in intercellular recognition. Objectives: Investigation of immunohistochemical expression of CD147 in  non-invasive and invasive ductal carcinomas and correlation of this  expression with the clinico-pathological aspects of the tumors. Materials and methods: 50 formalin fixed paraffin embedded BC tissue  sections were randomly collected. All the available data were collected from  the patients{u2019} reports. The paraffin blocks were sectioned, stained with  hematoxylin&eosin stainsfor histologic evaluation. Additional sections were  immunostained with CD147.Results: CD147 (EMMPRIN) immunohistochemical expression was  positive (48%) mild in 11 cases (22%), moderate in 8 cases (16%), severe in  5 cases (10%), and negative in 26 cases (52%). and showed statistically  significant correlation with any of the studied parameters (P value < 0.005).
ER  -