TY  - BOOK
AU  - Ramy Sayed Aboelella Ahmed
AU  - Diaa Abdelsamei , 
AU  - Fatma Abdelfattah Ragab , 
AU  - Sahar Mahmoud Abouseri , 
TI  - Design and synthesis of thieno[2,3-d]pyrimidine derivatives and their biological evaluation as Antitumor and anti-HIV agents / 
PY  - 2016///
CY  - Cairo : 
PB  - Ramy Sayed Aboelella Ahmed , 
KW  - EGFR
KW  - MCF-7
KW  - Thienotriazolopyrimidine
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry; Issued also as CD
N2  - In a search for new cytotoxic agents with improved anticancer profile, some new thienopyrimidine and thienotriazolopyrimidine derivatives were synthesized. All the synthesized compounds are tested for their in-vitro cytotoxicity against human breast cancer cell line (MCF-7) in which tyrosine kinases are highly expressed. All target compounds are then subjected for further evaluation against receptor tyrosine kinase enzymes; namely, epidermal growth factor receptor (EGFR), (ErbB-2) and vascular endothelial growth factor receptor-2 (VEGFR-2).Compounds in series I were designed to be nonnucleoside reverse transcriptase inhibitors (NNRTIs). Compounds Va-f were assayed for their inhibitory activity against HIV-1 (IIIB strain) and HIV-2 (ROD strain) using nevirapine as a reference inhibitor. They were found to be moderately active against reverse transcriptase
ER  -