Carbetocin versus oxytocin for the prevention of atonic postpartum hemorrhage after repeated elective cesarean sections /
مقارنة بين عقار الكاربيتوسين و الاوكسيتوسين فى الوقاية من نزيف ما بعد الولادة القيصرية المتكررة
Samah Yehia Ahmed Sayed ; Supervised Salah Ali Sanad , Eman Ali Heussin
- Cairo : Samah Yehia Ahmed Sayed , 2016
- 108 P. : charts , facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Gynecology and Obstetrics
To compare the effect of carbetocin versus oxytocin in prevention of postpartum hemorrhage after repeated elective cesarean section. Randomized controlled prospective study on 50 women were going to do repeated elective cesarean section after 38 weeks. They were randomized to receive 100 microgram of carbetocin and 5 units of oxytocin followed by 20-40 units of IV oxytocin infusion. The primary outcomes were to compare the occurrence of major obstetric hemorrhage and need for uterine massage and additional uterotonic agents. Secondary outcomes included estimated mean operative loss, objective changes in hemoglobin and hematocrit, preoperative and postoperative blood pressure and pulse, severe anemia and need for blood transfusion. Patients received carbetocin developed less postpartum hemorrhage, required less intervention with less mean operative blood loss than oxytocin, with nearly similar safety profile carbetocin seems to be more effective in maintaining adequate uterine tone and preventing excessive blood loss in. Patients undergoing repeated elective cesarean section. Carbetocin was well tolerated with nearly similar safety profile to oxytocin