Doaa Mahmoud Abdelhamid Garhy  <br/><br/>
Biopharmaceutical study on selected improved carvedilol formulae in a certain dosage form /  
 دراسة بيوصيدلية لأشكال معدلة ومختارة من عقار الكارفيديلول فى شكل معين 
Doaa Mahmoud Abdelhamid Garhy  ;supervised Mahmoud M. Ghorab , Howaida K. Ibrahim , Soha A. Ismail  
 - Cairo :   Doaa Mahmoud Abdelhamid Garhy ,   2016 
 - 182 P. :   charts , facsimiles ;   25cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics 
<br/><br/> Novel drug delivery dosage forms can provide improved benefits as enhancement in bioavailability, reduction of adverse effects and economic benefits. Elderly people may experience deterioration in  their physiological and physical abilities which may lead to  encountering difficulties in taking conventional dosage forms due to dysphagia. Carvedilol is Ü1/ non-cardioselective Ý-blocker that is used in the treatment of hypertension and many cardiovascular disorders. It is insoluble in water, intestinal fluids and gastric fluids that undergoes extensive first pass effect and has oral bioavailability of only 25-35%. Therefore, the aim of this thesis is to enhance the bioavailability through preparation of carvedilol nanoparticles to enhance dissolution and so absorption. Also, incorporation of the prepared nanoparticles in a gel form for buccal application to bypass the first pass effect and  enhance the bioavailability 
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<br/><br/><label>Subjects--Index Terms: </label>Carvedilol formulae Certain dosage form Pharmaceutics