Samira Zakaria Ahmed  <br/><br/>
Rtrospective and prospective study of the Interrelation between  Interleukin-28B and Endogenous Interferon Gamma in human infected with Hepatitis-C Virus and/or Schistosoma mansoni /  
 درا ا ذات ا ر   ا ٢٨-  واون  ذا ا  ا ا وس اب  ا ا  ا أو  ا  رسيا المستقيم 
Samira Zakaria Ahmed ; Supervised Magdy Ali Amin , Samuel T. Melek , Nourtan F. Abdeltawab  
 - Cairo :   Samira Zakaria Ahmed ,   2016 
 - 104 P. :   charts , facsimils ;   25 cm 
<br/><br/>Thesis (M.Sc.) - Cairo University -Faculty of Pharmacy - Department of Microbiology and Immunology  
<br/><br/> Intestinal schistosomiasis and hepatitis C viral (HCV) infections are endemic in  Egypt with the highest prevalence worldwide. Co-infections are common in Egypt leading  to severe liver diseases. Several studies have been concerned with the characterization of  immune responses in S. mansoni/HCV co-infection in relation to treatment. The different  natures of viral and parasitic infections have raised questions on how the immune system combats HCV/S. mansoni co-infection. Thus, many studies were undergone to address this particular question. Although studies on genetic polymorphism in interleukin 28B (IL-28B)  gene had shown promising results in predicting a HCV patients response to antiviral  therapy, IL-28B plasma levels role in treatment-naïve chronic co-infection is still not clear.  Therefore, a case-control study was performed to investigate the behaviour and  correlation between IL-28B and gamma interferon (IFN-Þ), two distinguished immune markers in both HCV and S. mansoni infections. The study included a total of 126 patients recruited from Cairo and Nile Delta attending Kasr Al-Aini Hospital, Cairo, Egypt 2012 2014. Subjects (n = 107) meeting our inclusion criteria, 57% from Cairo and 43% from Nile  Delta, were divided to three groups; treatment-naïve chronic HCV-4 patients (n = 50), S.  mansoni/HCV co-infected patients (n = 22) and healthy controls (n = 35). Clinical history  and liver function markers were determined for each participant. Plasma levels of IL-28B  and IFN-Þ were assayed for all participants by ELISA. HCV viral load was quantified using  Real-Time PCR. In addition, plasma anti-schistosoma antibody titers were assayed along  with rectal snips and microscopic stool examination for identification of viable S. mansoni  viable eggs in feces 
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<br/><br/><label>Subjects--Index Terms: </label>co-infection  Hepatitis C virus Schistosoma mansoni