TY  - BOOK
AU  - Basma Abdelalim Zakaria 
AU  - Dalia Elrouby , 
AU  - Laila Rashid , 
AU  - Tarek Hamed Shuman , 
TI  - Effect of transplantation of bone marrow  derived mesenchymal stem cells and platelets rich plasma on experimental model of radiation induced oral mucosal injury In albino rats : : Animal study / 
PY  - 2016///
CY  - Cairo : 
PB  - Basma Abdelalim Zakaria , 
KW  - BM-MSCs
KW  - Oral mucositis
KW  - Radiotherapy
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Oral (diagnosis); Issued also as CD
N2  -  Normal tissue damage following radiotherapy (RT) is still a major problem in cancer treatment. Therefore, the current work aimed at exploring the possible role of systemically injected bone marrow derived mesenchymal stem cells (BM-MSCs) and  /or locally injected platelet rich plasma (PRP) in ameliorating the side effects of ionizing radiation on the rat's tongue. Materials & Methods: 12 rats served as control group (N) and 48 rats received a single radiation dose of 13 Gy to the head and neck region, then, they were equally divided into 4 experimental groups: Irradiated only  group (C), Irradiated+MSCs group (S), Irradiated + platelet-rich plasma (PRP) group  (P) and Combined group (PS). The animals in each group were divided into two blocks  as animal sacrifice occurred in 3, 7 days after radiation. Then, tongues were dissected and examined histologically and for expression of bcl-2 by RT-PCR. Results: Histological examination of the treated groups (S), (P) and (PS) revealed an obvious  improvement in the histological structure of the tongue; compared to the irradiated  group (C); in addition to up regulated expression of bcl-2, indicating decreased apoptotic activity. Conclusion: BM-MSCs and PRP have shown positive effect in protection against the side effects of radiotherapy on normal oral mucosa, which was emphasized by decreasing apoptotic activity in these tissues. Nevertheless, combined use of both BM-MSCs and PRP did not reveal the assumed synergetic effect in oral  tissue protection
ER  -