Lamiaa Ahmed Fouad Ali <br/><br/>
IL-21R polymorphism and response to treatment by interferon in Egyptian patients with chronic hepatitis C-CHC /  
 التنوع الجينى لمستقبلات الانترلوكين 21 و الاستجابة للعلاج بالانترفيرون فى المرضى المصريين المصابين بالتهاب الكبد المزمن سى 
Lamiaa Ahmed Fouad Ali ; Supervised Magda Ahmed Abdallah , Heba Mohamed Kamal , Amal Ahmed Mohamed 
 - Cairo :   Lamiaa Ahmed Fouad Ali ,   2016 
 - 131 P. :   charts ;   25cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biochemistry 
<br/><br/> HCV is a major cause of CHC. Egypt has the highest rate of HCV infection (genotype 4) in the world. IL-21R gene polymorphism is recently studied as pretreatment predictor in CHC patients treated with peg-INFplus ribavirin. In this study, we focus on evaluate of blood IL-21R gene polymorphism in CHC genotype 4 Egyptian patients and investigate it is benefit as a pretreatment predictor of  antiviral response. This prospective study was carried out on 80 chronic hepatitis C (CHC) genotype 4 patients. All 80 CHC patients were subjected to treatment with pegylated Interferon alpha-2a (180 mcg subcutaneously  once weekly for 48 weeks) plus ribavirin (1000-1200 mg/day according to body weight less or greater than 75 Kg) from January 2014 to January 2015. At the end of treatment our patients were divided into two groups; responders (44 patients) and non-responders (36 patients), all patients were subjected to different biochemical and IL-21R genotyping analyses. In conclusion, patients with IL-21R rs3093390 CC genotype had a higher sustained virological response to peg-INF treatment than those with non-CC genotypes 
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<br/><br/><label>Subjects--Index Terms: </label>Genotype 4 Hepatitis C virus Interleukin 21 and interleukin 21 receptor