Samy Abdalla Mehany Habib <br/><br/>
N-linked metatonin dimers as bivalent ligands targeting dimeric melatonin receptors /  
 كمركبات ثنائية التكافؤ تستهدف مستقبلات الميلاتونين المثنوية N- مركبات ميلاتونين ثنائية الوحدات مرتبطة عن طريق 
Samy Abdalla Mehany Habib ; Supervsied Darius P. Zlotos 
 - Cairo :   Samy Abdalla Mehany Habib ,   2014 
 - 118 Leaves ;   30cm 
<br/><br/>Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceulical Chemistry 
<br/><br/> The diverse physiological actions of the pineal neurohormone melatonin are mainly mediated through activation of two G-protein-coupled receptors MT₁, and MT₂. These receptors are known to form homo-and heterodimers with distinct functions and properties opening new perspectives for drug design and drug treatment. The bivalent ligand approach is a common strategy for targeting dimeric GPCRs 
<br/><br/><label>Subjects--Index Terms: </label>Dimeric melatonin receptors N-linked metatonin dimers  Targeting dimeric GPCRs