Marco Kerolos Abdallah Kerolos Rizk <br/><br/>
Optimization of valproic acid-loaded lipid nanocapsules for potential nose-to-brain targeting /  
 تحسين صياغات كبسولات نانونية دهنية محملة بعقار حمض الفالبوريك لرفع احتمالية تهديف العقار للمخ عن طريق الأنف 
Marco Kerolos Abdallah Kerolos Rizk ; Supervsied Nagia Nagib Afifi , Rania Mohammed Hathout , Reham Mahmoud Abdelkader 
 - Cairo :   Marco Kerolos Abdallah Kerolos Rizk ,   2014 
 - 77 Leaves :   charts , facsimiles , photographs ;   30cm 
<br/><br/>Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Technology 
<br/><br/> Valproic acid ias an important drug for its role in the treatment of epilepay as well as other CNS disorders. Unfortunately, it suffers from two main problems, its poor brain bioavailability owing to ecessive binding to plasma proteins and its efflux outside the brain by the action of P-gp pumps. Accordingly, higher doses are needed resulting in serious side effects such as liver toxicity. Morcover, the conventional dosage forms of the drug which are available now in the market offer less than 10% brain bioavailability 
<br/><br/><label>Subjects--Index Terms: </label>Lipid nanocapsules Potential nose-to-brain targeting  Valproic acid-loaded