TY  - BOOK
AU  - Marco Kerolos Abdallah Kerolos Rizk
AU  - Nagia Nagib Afifi , 
AU  - Rania Mohammed Hathout , 
AU  - Reham Mahmoud Abdelkader , 
TI  - Optimization of valproic acid-loaded lipid nanocapsules for potential nose-to-brain targeting / 
PY  - 2014///
CY  - Cairo : 
PB  - Marco Kerolos Abdallah Kerolos Rizk , 
KW  - Lipid nanocapsules
KW  - Potential nose-to-brain targeting
KW  - Valproic acid-loaded
N1  - Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Technology
N2  - Valproic acid ias an important drug for its role in the treatment of epilepay as well as other CNS disorders. Unfortunately, it suffers from two main problems, its poor brain bioavailability owing to ecessive binding to plasma proteins and its efflux outside the brain by the action of P-gp pumps. Accordingly, higher doses are needed resulting in serious side effects such as liver toxicity. Morcover, the conventional dosage forms of the drug which are available now in the market offer less than 10% brain bioavailability
UR  - http://172.23.153.220/th.pdf
ER  -