TY  - BOOK
AU  - Mirna Sherif Sadek
AU  - Darius P. Zlotos , 
TI  - O-linked and NI-linked melatonin dimers as bivalent ligands targeting dimeric melatonin receptors / 
PY  - 2014///
CY  - Cairo : 
PB  - Mirna Sherif Sadek , 
KW  - Melatonin
KW  - O-linked and NI-linked
KW  - Targeting dimeric
N1  - Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceulical Chemistry
N2  - Melatonin, the key regulator of the sleep/wake cycle, is a neurohormone secreted primarily from the pineal gland and mediates most of its various physiological functions via activation of two G-protein-coupled receptors,MI₁ and MI₂. The latter were recently reported for their ability to form homo-and heterodimers with distinct physiological functions, thus opening new perspectives for drug design and drug treatment. The most popular technique used to target dimeric GPCRs is the bivalent lignad approch. To the best of our knowledge bivalent melatonergic ligands have never been used to explore the dimerization of melatonin receptors
UR  - http://172.23.153.220/th.pdf
ER  -