TY  - BOOK
AU  - Heba Ali Mohamed Shendy
AU  - Mohamed Z. Gad , 
AU  - Sally Ibrahim Hassanein , 
TI  - A novel cohort study of Chr9p21 (desert gene) genetic variants in cardiovascular patients with type-2 diabetes / 
PY  - 2015///
CY  - Cairo : 
PB  - Heba Ali Mohamed Shendy , 
KW  - Cardiovascular patients
KW  - Chr9p21
KW  - Type-2 diabetes
N1  - Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Biochemistry
N2  - Cardiovascular disease is a leading cause of death worldwide. Chr9p21 locus happened to be the most robust genetic marker of CAD. The entire core of chr9p21 is covered by 'ANRIL' and lies in a region that is free from any coding proteins and therefore it is called the desert gene. Beside this region, are some protein coding genes, CDKN2A, CDKN2B. The association mechanisms for chr9p21 with atherosclerotic disease are vague but, it was suggested that ANRIL, influences the regulation of the epigenetic modification and thus modulate cardiovascular risk, as its expression is highly detected in vascular tissues related to atherosclerosis
UR  - http://172.23.153.220/th.pdf
ER  -