TY  - BOOK
AU  - Amr Adel Waly
AU  - Ahmed Ihab Abdelaziz , 
AU  - Hand Mohamed Eltayebi , 
TI  - Epigenetics of the Epigenetics : : Hypermethylation of microRNA let-7a-3 gene represses the primary and mature let-7a with an inverse correlation to IGF-II mRNA in HCV-induced hepatocellular carcinoma / 
PY  - 2013///
CY  - Cairo : 
PB  - Amr Adel Waly , 
KW  - Hepatocellular carcinoma (HCC)
KW  - IGF-II mRNA
KW  - microRNA let-7a-3 gene
N1  - Thesis (M.Sc.) - Cairo University - Garman University - Faculty of Postgraduate Studies and Scientific Research- Department of Molecular Pharmacology
N2  - Ongoing research has been focusing on the impact of the interplay between epigenetic mechanisms on malignant transformation. This work investigated the crosstalk between two of the epigenetic mechanisms: DNA methylation and microRNAs, in hepatocellular carcinoma (HCC).  MicroRNA let-7a is a member of the arechetypal let-7a miRNA gene family. Owing to its know tumor suppressor activity, aberrant expression of microRNA let-7a was found to deregulate ~200 gene involved in cell proliferation, differentiation and adhesion
UR  - http://172.23.153.220/th.pdf
ER  -