Ahmed Kamal Mohammed Elhady <br/><br/>
Design and synthesis of novel tetrahydrobeta-carbolines with a hydrophlilc side chain as potential phosphdiesterase 5 inhibitors and anticancer agents /  
Ahmed Kamal Mohammed Elhady ; Supervised Ashraf H. Abadi , Nazih Noureldin , Nermin Salah 
 - Cairo :   Ahmed Kamal Mohammed Elhady ,   2015 
 - 110 Leaves :   charts ;   30cm 
<br/><br/>Thesis (M.Sc.) - Garman University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry 
<br/><br/> PDE5 enzyme is expressed in various parts of the human body, and thus PDE5 inhibitors has as PDE5 inhibitors for the treatment of MED and PAH, one of the most potent orreversble inhibitors of PDE5 enzyme currently present in the market it tadalafil; tadalafil is chemically classified as a tetrahydro-Ý- carboline-based PDE5 inhibitors. Recent studies showed that PDE5 and other PDEs are over-expressed in malignant tumors, thus inibiting these PDEs and the consequent rise of cGMP levels can lead to apoptosis and anticancer activities. 
<br/><br/><label>Subjects--Index Terms: </label>Hydrophlilc side chain Novel tetrahydrobeta-carbolines Potential phosphdiesterase 5