TY  - BOOK
AU  - Ahmed Kamal Mohammed Elhady
AU  - Ashraf H. Abadi , 
AU  - Nazih Noureldin , 
AU  - Nermin Salah , 
TI  - Design and synthesis of novel tetrahydrobeta-carbolines with a hydrophlilc side chain as potential phosphdiesterase 5 inhibitors and anticancer agents / 
PY  - 2015///
CY  - Cairo : 
PB  - Ahmed Kamal Mohammed Elhady , 
KW  - Hydrophlilc side chain
KW  - Novel tetrahydrobeta-carbolines
KW  - Potential phosphdiesterase 5
N1  - Thesis (M.Sc.) - Garman University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry
N2  - PDE5 enzyme is expressed in various parts of the human body, and thus PDE5 inhibitors has as PDE5 inhibitors for the treatment of MED and PAH, one of the most potent orreversble inhibitors of PDE5 enzyme currently present in the market it tadalafil; tadalafil is chemically classified as a tetrahydro-Ý- carboline-based PDE5 inhibitors. Recent studies showed that PDE5 and other PDEs are over-expressed in malignant tumors, thus inibiting these PDEs and the consequent rise of cGMP levels can lead to apoptosis and anticancer activities
UR  - http://172.23.153.220/th.pdf
ER  -